Here are my thoughts:
1. Definitely AIM. You're not using a shotgun.
2. Stance - "fighter's stance" with 2/3 of your weight on your front foot and 1/3 weight on your rear foot.
3. Sequence - forward trigger first, aft trigger second.
4. Reloading - practice to see what works for you. I "thought" that 2 rounds in my forward hand while shooting (left for me) would provide for the fastest reload, based on my reading of books.
(It didn't, for me, in actual practice)
5. Unfortunately, I don't trust my reloads as well as I do Hornady or Federal factory ammo. (My reloads (Barnes TSX, just never shot as well).
After thoughts...
If I can't get within 50 yards, then my open-sighted DR becomes the limiting factor.
I take a scoped bolt action, also.
On my 2021 trip, I could never get close enough to use my DR for buffalo, so I had to make a 70+ yard (somewhat obscured) shot with a scoped .416 Rigby.
He did the "death bellow," which was absolutely awesome.
It was a one-shot kill, if my PH wanted it to bleed out, but he wanted me to put 2 additional shots into him.
I did, and he just rolled over and it was done.
I wanted the opportunity to "stop a charge," but my first shot was sufficient.
In hindsight, a fatal shot the first time, beats a wounding shot every time.