Ever since I returned from my last trip to Africa, I've been mulling over the whole stopping rifle idea in my head. I must admit that when I was on the trail of my wounded Cape Buffalo, I would've really liked to have had something larger than my 375 in my hands. I had a 416 back at camp, but we had no time to retrieve it. (I wish I had just used the 416 in the first place). That said, I do see the validity of a client bringing along two rifles with two very different purposes. One rifle that's suited for PG and DG hunting. A 375 or 416 would fill this order, but a 416 just seems too much of a good thing when it comes to game the size of Impala, or Blesbuck. So that leaves us with a 375 for the most part. I believe the 375 has proven itself plenty capable as a dual purpose cartridge, and as a reasonably effective Cape Buffalo cartridge, for a client. The other rifle would be for following up dangerous game that has been wounded, or used for Buffalo hunting in thick vegetation, where the shots are close. This rifle would be taken along on all hunts. At the very least, in the truck. So the question is, how much REAL difference in stopping power is there between the various 458/470 caliber rifles vs something like a 500 Jeffrey, 505 Gibbs or 500 Nitro?