I've been doing some thinking, since I returned from Africa on my recent Cape Buffalo, and plains game hunt. I shot 7 animals with my 375 H&H Kimber Talkeetna and Swift A Frame bullets, and a Cape Buffalo with my Winchester 416 Rem mag., with the same Swift bullets. All were clean kills and bullet performance was excellent. I also went to Austalia in 2015 and killed 3 Water Buffalo bulls with my 375 H&H Sako Kodiak, with Barnes TSX 300gr bullets. All were clean kills as well. None of the bulls ran out of sight before falling over. (I still kept pouring the lead to them). So, that being said, I wonder how much more effective is a 416 really over a 375 with heavy bullets and or Barnes bullets? Do I REALLY need to take 2 rifles next time???