I've taken a Sako 75 in 338WM on both of my African trips. 225gr is the ideal bullet weight for the calibre IMHO. I've used Nosler Accubonds and Woodleigh PPs successfully. But as the OP suggested, if you use Barnes bullets I would go light for calibre to get them moving as fast as possible. I don't know if Barnes makes them in 180gr but I reckon it would work well.
My PH advised against mono bullets on plains game because of the risk of pass-through and hitting another (possibly unseen) animal.
Photo of my son's Eland taken with 338WM.
My PH advised against mono bullets on plains game because of the risk of pass-through and hitting another (possibly unseen) animal.
Photo of my son's Eland taken with 338WM.