I have the same rifle and it loves 68 grs of R22 with the 200 gr Nosler Partition. I get about 2900 fps based on the same load getting 2850 in a 24 inch barreled Rem 700. Its a very accurate load. I also had good luck with the 180 Barnes TTSX using R22 and H4831, but in a .300 mag I prefer 200 grs, as I think the 180 is better suited to the '06. Now having said that the load I am taking to Namibia next month for Eland is that same 200 gr Partition in my Ruger '06. My load is a full max load by Nosler anyway, of 58 grs of R22 that clocks at just over 2600 fps for 3000 ME. Should be a good load, reliably accurate. Why am I taking an '06 instead of something more exotic? Simple. I have never hunted with an '06 before, anywhere.