I used 260 AB's in my 375 H&H (~2620fps MV) on my last SA hunt. Eland, Sable, Gnu, Bushpig, Impala, White Blesbuck, Nyala. 10 to 280yrds. Excellent choice by my measure and would happily use them again.
I've never shot a Buffalo, but Judging by their penetration and expansion, I would...