My father has shot a lot of pronghorn and whitetail with a 243. Not so great for larger whitetail in south Texas, he moved up to a 270 for a whitetail gun. I've used a 243 to shoot a lot of deer too, but I've moved up to a 308 as my go to deer gun. I do like the no recoil, fast speed and very flat shooting of the 243. My only concerned with the 6 rem v the 243 win would be buying ammo off the shelf. Not sure if I can walk into the Walmart and get the 6, but I know with the 243 I can walk into just about any store selling ammo and get some. Of course, if you are loading your own and take plenty with you it's not a problem. As others have said the biggest problem, is how to convince mama, that you need another gun.