Put them in the right spot and it will kill them. Personally I would probably go with a 210-225grain Barnes TTSX, but the Accubond will work. Lots of people have killed the biggest antelope in the world with nothing more than a 7x57... Granted, you gotta be a good shot and know your animals anatomy from any angle. I spend lots of time at the range all year so that when an animal steps in front of me, I don't even have to think about the aspects of shooting, they are all just habit at that point. Practice with your .338 until you can put all of your shots in a pie plate, offhand, at 100 yards and you'll be good to go. Most African PH's use shooting sticks whenever there is time to set them up and I doubt they will ask you to shoot offhand at a running antelope at 300 yards, although I'm sure there are game shots that could do it.
I think a lot of people concentrate on being a good shot, and while that is important, not all of them study the internal structure of the animal very closely. It is true that most quadrapeds vitals are in SIMILAR places, but there is a difference in all of them. Spend a fair amount of time looking up eland pictures, or wildebeest pictures from all sorts of different angles and imagine where you would put your round to do the most good. When you get into the field, it will be second nature. It has always worked for me!
Once you are armed with the knowledge of vitals on the animals and you have practiced with your rifle until you are comfortable that you can hit those vitals from any angle at any reasonable range, and you can do it from various field positions, caliber and bullet become far less important. I am not suggesting someone shoot a cape eland with a .243, you have come a long way and paid lots of money to hunt. Your .338 is more than enough gun for any thin skinned game on the planet. It's a big enough gun to bust bones with a modern bonded or monometal bullet and just put it through the pump room. The rest will sort itself out. Have fun and best of luck!