I load the Woodleigh 350g HD softpoints to 2550 out my 375 Weatherby. Awesome bullet, designed for those velocities. Only shot paper with them so far. Got my brown bear with a 300g A-Frame at 375 H&H velocities (was using 375 H&H factory ammo). Bullet traversed an 8 1/2' brown bear diagonally and still weighed 299.5 grains