One last chirp - for what it's worth. Modern firearm ballistics have exceeded bullet construction technology. Just an observation but may of the comments above are owners with calibers I have never been fond of for Africa due to time wasted looking for wounded animals - many with good shot placement. In broad terms I divide calibers into "varmit" and "hunting". Varmit calibers are generally high speed flat shooting like 22-250, 220 Swift, 25-06, 6.5-06 etc. Great for shooting over a bench with big scopes and blowing prarie dogs to kingdom come at over 3000ft/sec. But they were never designed for hunting larger game with ANY bullet. Most clients are amazed at how tough African game is - and I'm not talking big five. Hunting calibers are all, to me, mininum .30 with the exception of .222 and .223 which have taken thousands of springbuck. .243 will do the job too, but often destroying a lot of meat and sometimes the cape. 7mm mags, and even O'Conner's famous .270 have failed us here often. Same goes for 338mags - just not necessary. I can't explain why, but in general, here are my feelings - based on experience, when choosing a rifle for Africa. Don't get carried away with ballistics charts and hot loads or super magnums. Plains game - your PH should get you within 150m of your target and never allow a client to try a shot at over 200m. That's his job. Many shots will be 50-100m. 1) Minimum .30 cal. - 308, 30-06, or a 300mag - except Weatherby. Even these calibers can fail with hot loads, light bullets etc. So I suggest 165gr and 180gr for the mags. 2) Ballistics - If a 7X57 was so successful in Africa then a 7mm Rem mag must be better - right? Wrong. If we all agree that any shot resulting in a "through & through" or that disintegrates in impact with bone is a disaster resulting in may wounded and often lost animals. Speed does not kill. A good kill usually results from at least 50% bullet mass retention and no exit. Speed and energy are meaningless if they are absorbed. Here is the catch - factory ammo usually works just fine. No fancy bullet technology - just that they are loaded at the "recommended" speed for the above calibers. For those of us who hand load, superior heads will usually provide better results - if, and only if, you stick to the recommended speed. The most important factor is find a speed which gives you the best grouping and accuracy for the heads you want to use. 3) Optics - Off topic but "Keep it simple". Most Americans and Europeans have little experience at judging distance over open ground - especially when the target size varies from a Duiker to an Eland. Like bullet speed, 14X is not better than 4X - unless you want to see your own heartbeat. Vari-powers often confuse the shooter and there often isn't time to adjust and fiddle. So, before you start looking for the "perfect bullet", think about this. It's not the bullet that is responsible for a successful hunt. It is your shooting skill, shot placement, and a caliber proven to do the job. There is no perfect bullet, perfect rifle or perfect hunter. You can have a great Safari with a 30-06, factory 165 or 180gr ammo, and a decent 4X scope. Use a rifle you are comfortable and confident with, use a bullet which is a good weight, find a speed thst gives a good grouping at 100m - and most importantly, like golf, go to the range and practice regularly. And, remember, once you are competent and confident at the range, when you get the opportunity for that trophy of a lifetime, you will probably be out of breath, shaking, and nervous so you cannot have doubts in the back of your mind about your equipment. Even at my age, I can feel my heart pounding when I look at a trophy Kudu bull through the scope. I've seen too many experienced hunters arrive in Africa arrive here with a brand new Weatherby and a huge scope - because of something they read - but their experience was only hunting deer with a 30-30. They usually finished the hunt with my old Mod 70 06 - and factory ammo. As for big game hunting - then 375H&H with good factory ammo 270-300g is next - that's all you need. Technology is great, but most of our best hunting calibers are nearly a century old and, in my mind, nothing has ever replaced them. John "Pondoro" Taylor's African Rifles and Cartridges (1948) is still relevant today and often "slower is better". Bullets fail due to excessive speed more often than design.