As everyone else has said, it depends.
I think the most generally applicable answer would be to pick the smallest animal you plan to shoot, figure out the size of its vitals, then calculate maximum point blank range for the load you are using.
The specific answer could be very different and depends on what you are exactly planning to do. For example, with a typical leopard hunt, one can zero for the expected shot since there is bait and there is a stand at a fixed distance. The same would work for a water hole from a stand, albeit with a bit more variability in range than a leopard on a known particular tree branch.
The old 2 inches high at 100y for most plains game rounds is not a bad option as a rule of thumb for most situations most of the time. To the extent that it is less than ideal, that is probably because there are known specific circumstances in which case, you would be able to take those into account.