Nah, simply a matter of time and acclimating yourself. There are some exceptions. I shot a .505 Gibbs once and I'm done....forever. No intention of ever shooting one of those again.
But a .375 is a piece of cake now. Load up some lighter bullets and it really extends the time. The last time I shot my .458B&M, somewhere between a .458 Win and .458 Lott, I touched off more than 20 rounds. Half of those were 250gr bullets that are just a hoot to shoot. Besides if you shoot at a public range like I do, it's kind of fun to see other shooters going all giddy over the size of the bullets your shooting. (Okay, perhaps that's some sort of compensation issue)
Will you want to touch off 50 rounds the way you might a .223, doubt it. But it's not a one and done and honestly if you're planning a DG hunt, you really need to spend range time to where you're not afraid of the rifle so that you are only focused on that big bad whatever that will stomp/bite you when you cause it to leak.