Hello, Having only shot one buffalo I am but a toddler on the subject. However, I speak with anyone who hunts big game (and who is foolish enough to hold still for a minute), about hunting, especially rifles/sights/scopes and bullet related topics. The common opinion among several PHs that I have cornered on this, is that most (not all, but most) prefer clients who are not rifle nuts, to use a sturdy bolt action with low power scope in .375 H&H. They told me they like clients to shoot 300 grain Swift A-Frame for the first shot and 300 gr monolithic solids with a flat tip AKA "meplat" or similar shape for all follow-up shots. Also, it is worth mentioning that all but one of the PHs I have had the great pleasure of conversing with about buffalo hunting (and hunting in general) either have a .458 Lott and prefer it for their own buffalo hunting, plus backing up clients or they have a .458 3" but loaded to the same ballistics as the others generally load the Lott version (2.85" ?). In those, they use the 500 gr A-Frame for their first shot when hunting and 500 gr solids for follow-ups and backing clients of course. To quote John Luyt of Duke Safaris, "I've never seen a Swift A-Frame fail". Cheers, Velo Dog.