I have taken Lariam since 1995 with no side effects. I have seen clients that were travelling with me have the vivid nightmares and mood swings that you sometimes hear about. I will be in Zimbabwe from April until October this year and last year switched to Doxycycline. I had no ill effects and it is much less expensive than the other meds. The doxy also is a mild antibiotic which can have the added benefit of staving off infections etc. I checked with a travel physician last year prior to switching to the doxy and he highly endorsed it.