Recently returned from RSA plains game hunt (Limpopo) & used a 375ruger on 6 species from Warthog to Kudu. Gun/cartidge performed great, (a lot better than I did) using 270gn Hornady factory ammo. All one shot kills from 60 to 140 metres & only one exit wound (on Impala at 60 mts & no...not bragging just making a point about the ammo). I'm going back in 2012 for buffalo & Sable & would like to hear from anyone that has used this cal. & 300 gn factory on buffs. Also does anyone know if other manufacturers are looking at producing a round for the 375Ruger. By the way met some of the best people in world in RSA.