.308 On plains game
I agree with all the contributors on the merits of the .308. It is an extremely popular caliber in South Africa and if you do your bit it wont let you down. If I may comment on the Blue Wildebeest, it has a smaller frame than Kudu for instance. But pound for pound it is one of the toughest game animals in Africa. Study bullet placement on the Wildebeest, take it through the boiler room and it has to go down.
Happy Hunting