243 I guess I will have to play the devils advocate as I am not a fan of the .243 for a number of reasons..I tried it out several times on deer and antelope and varmints...It was bad about leaving good blood trails IMO and in many cases you won't get a blood trail at all on big game, even with bullets like Nosler or Barnes X as the hole just isn't large enough in all cases... Also the .243 is the number one caliber of all time for blowing up according to Winchester figures..Apparantly this is caused by throat erosion and the use of either light of heavy bullets, can't recall which just off hand..This was a study done by Win. to correct the problem..That information was published in an old gun magazine sometime ago and was a study done by Winchester as I recall...At any rate I much prefer the .257 Robts or the 250 Savage... I do however have a wonderful little 5 lb. 6x45, and that is a caliber I am quite fond of for hunting coyotes and with carefull use and a hoarded batch of Barnes X 75 gr. HPs it is effective on Deer and Antelope in open country where you can watch them run a bit before the expire, as would be the .243. Just a personal opinnion and certainly argueable..