2 Rifle combination
Last year and this year, I have used a Weatherby Fibermark Mark V in .340 Weatherby caliber and using 250 grain Nosler bullets for plains game, and a Ruger Hawkeye Alaskan in 416 Ruger with Hornady DGX bullet for a Black Maned Lion and a 41" Cape Buffalo. The combination resulted in quick kills. Specifically, the Lion and Cape Buffalo were taken with single shot kills.
Shots were taken from 23 yards to over 400 yards, and I believe this combination is very adequate to take any African game that you may encounter.
No argument from me, plenty of fire power!